J
jenny
Guest
ohmigish thats possible?!
can it be done on any animal?
can it be done on any animal?
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Axolotls are illegal in California. Please read this thread for detailed information and links to the actual laws: https://www.caudata.org/threads/axolotls-are-illegal-in-california-here-are-the-relevant-laws.30779/
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mike
Active member
- Joined
- Jun 17, 2003
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- Dorset, England.
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- Mike East
Thanks Gals and Guy,
Source: Science for Life, Tokyo University Digital Museum.
Source: Science for Life, Tokyo University Digital Museum.
L
lauren
Guest
They use the chimera technique for mutant studies. If a mutant is destined to die of some mutation in the head or chest before it can be studied, they make a chimera out of a normal upper half and a mutant lower half w/ gonads. When they reach adulthood, they can breed 2 chimeras and be assured of 100% mutant eggs, which they can study at all stages. With regular carriers they would only be assured of 25% mutant eggs, and they would not be noticable until they were already dying.
They do make chimeras by cutting the embryos in half and then holding the halves together for 24 hours in a form. They fuse by themselves.
Incidently, I saw a wildtype-leucistic chimera today that looked just like the picture Mike posted, but it was completely normal. This is because you have to do the procedure way before the symptoms set in, so you don't know whether you've linked a mutant with a normal until much later - either through breeding or seeing if they chimera you made with the potentially affected parts dies. Sometimes the potentially affected half is kept alive in Holtfeter's solution until the point at which symptoms set in.
And I probably just gave everyone on this board nightmares for weeks. ;P
(Message edited by Lollia on February 12, 2005)
They do make chimeras by cutting the embryos in half and then holding the halves together for 24 hours in a form. They fuse by themselves.
Incidently, I saw a wildtype-leucistic chimera today that looked just like the picture Mike posted, but it was completely normal. This is because you have to do the procedure way before the symptoms set in, so you don't know whether you've linked a mutant with a normal until much later - either through breeding or seeing if they chimera you made with the potentially affected parts dies. Sometimes the potentially affected half is kept alive in Holtfeter's solution until the point at which symptoms set in.
And I probably just gave everyone on this board nightmares for weeks. ;P
(Message edited by Lollia on February 12, 2005)
L
lorraine
Guest
Chimaeras aren't that hard to make. People have been doing it with chickens and quail for years to study notochord development.
I did read a really great article about some scientists that were able to make chicken/prairie grouse chimeras. They took an endangered kind of grouse from Texas (only 40 or so left in the world) cloned a bunch of embryos, then spliced the section of the notochord corresponding with the gonads into some chicken embryos.
The result is chickens that don't hatch out baby chickens. They hatch out baby endangered grouse!
The benefit to this is:
1. Chickens aren't stressed by captivity
2. Chickens lay 365 eggs a year (As opposed to a dozen or so per year by the grouse)
3. Chickens breed well in captivity.
Apparently it was a big success, with hundreds of these grouse hatching out in a very short time. Seems like an effective way of saving those species "on the brink," or even bringing back an extinct one, since the problem of bringing a cloned embryo to full term isn't an issue here.
I did read a really great article about some scientists that were able to make chicken/prairie grouse chimeras. They took an endangered kind of grouse from Texas (only 40 or so left in the world) cloned a bunch of embryos, then spliced the section of the notochord corresponding with the gonads into some chicken embryos.
The result is chickens that don't hatch out baby chickens. They hatch out baby endangered grouse!
The benefit to this is:
1. Chickens aren't stressed by captivity
2. Chickens lay 365 eggs a year (As opposed to a dozen or so per year by the grouse)
3. Chickens breed well in captivity.
Apparently it was a big success, with hundreds of these grouse hatching out in a very short time. Seems like an effective way of saving those species "on the brink," or even bringing back an extinct one, since the problem of bringing a cloned embryo to full term isn't an issue here.