Well, certainly microorganism grown on sand partcles. My shrimps are always "cleaning" and "foraging" on sand particles...Yeah, pretty sure it doesnt kill bacteria...Algae definatly can grow on it, unless you have some crazy anti-bacterial coated sand and i doubt that. when you do water changes don't forget to stir up sand, because if you dont have a lot of plants rooting in it or snials burrowing in it, sand can compact and make a gas pocket or a bacterial pocket.
There are some plants that grow well with a sand substrate, some without. Just like you research when you get an axolotl, you should also research your plants. There are many that can live in a cold water sandy axolotl home. as for keeping them down, if you get a plant that throws out long roots, one only needs to place rocks on them until they get a hold in the substrate. if it is a non-rooting plant, either let it float or keep it down with multiple large and heavy rocks. The plants with small or no root structure easily can move when axolotl wants to play with them.
Really, dont take much of what pet shop people seriously, some make up wonderful tall tales.